Discovery of DS-1971a, a Potent Selective NaV1.7 Inhibitor.

Discovery of DS-1971a, a Potent Selective NaV1.7 Inhibitor.

A extremely potent, selective NaV1.7 inhibitor, DS-1971a has been found. Exploration of the left-hand phenyl ring of sulfonamide derivatives (I and II) led to the invention of novel collection of cycloalkane derivatives with excessive NaV1.7 inhibitory efficiency in vitro. As the right-hand heteroaromatic ring affected the mechanism-based inhibition legal responsibility of CYP3A4, substitute of this moiety resulted within the technology of 4-pyrimidyl derivatives. Additionally, GSH adducts formation, which may trigger idiosyncratic drug toxicity, was efficiently averted by this modification. An further optimization led to the invention of DS-1971a. In preclinical research, DS-1971a demonstrated extremely potent selective in vitro profile with strong efficacy in vivo. DS-1971a exhibited a favorable toxicological profile, which enabled multiple-dose research of as much as 600 mg bid or 400 mg tid (1200 mg/day) administered for 14 days to wholesome human males. DS-1971a is anticipated to exert potent efficacy in sufferers with peripheral neuropathic ache, with a favorable security profile.

Volatile anaesthetic brokers, particularly sevoflurane, could possibly be another for sedating ICU sufferers. In the working theatre, risky anaesthetic brokers are monitored utilizing minimal alveolar focus (MAC). In ICU, MAC could also be used to evaluate sedation degree and will exchange scientific scale particularly when they’re unusable. Therefore, we sought to research the minimal sevoflurane end-tidal focus to achieved deep sedation in vital ailing sufferers: MAC-deep sedation (MAC-DS).In a potential interventional examine, we included sufferers with a Richmond Assessment Sedation Score (RASS) of Zero with none sedation. We stepwise elevated sevoflurane focus degree earlier than assessing for deep sedation (RASS≤-3). MAC-DS was outlined because the minimal sevoflurane MAC fraction or sevoflurane expiratory fraction (FeSevo) to get 90% and 95% of sufferers in deep sedation (MAC-DS 90 and MAC-DS 95, respectively).Between June and November 2014, 30 sufferers had been included (median age=60 years [interquartile range: 47-69]). Increasing sevoflurane MAC was correlated with a lower in RASS values (r=-0.83, P<0.001).

Impact of childhood Dravet syndrome on care givers of sufferers with DS, a main impression on moms.

The intention of this examine was to grasp the impression of Dravet syndrome (DS) on sufferers with Dravet syndrome and their households, with a give attention to the social and financial impression on each moms and dads.A French language on-line survey was distributed (October 2014-January 2015) for completion by caregivers of sufferers aged <18 years with DS. The survey was hosted on the French Dravet Syndrome Alliance web site, and the survey hyperlink was offered to sufferers and caregivers throughout clinics on the Necker Hospital (Paris, France).Survey responses had been accessible for 91 sufferers (median age 7.6 years; 81.6% SCN1A mutation constructive). Total seizure frequency was >2 per week for 16.1% of sufferers, 1-Eight per thirty days for 55.2% and < 1 per thirty days for 28.7%; tonic-clonic and myoclonic had been probably the most frequent seizure varieties. Patients confirmed varied levels of mental incapacity and DS had a excessive impression on focus and faculty studying in 70.1% and 80.5%.
In addition, sufferers confirmed urge for food issues in 73.6%, sleep issues in 72.4% and conduct issues in 62.1%. Most dad and mom had been married (80.5%) with larger charges than the French normal inhabitants (53.5%). Educational achievement and socio-professional classes for the dad and mom had been larger than noticed within the French normal inhabitants, whereas month-to-month internet revenue was comparable. Preparation of medicine was typically performed by the mom and father (46.0% of sufferers) or the mom solely (37.9%). Most caregivers reported very low or no problem with therapy preparation and low or no danger of error. Parents usually spent <30 min per day on therapy preparation and administration and round Four h per week for attending remedy appointments.
Although most sufferers and oldsters had been perceived to have good normal well being, moms had a worse notion of their very own normal well being than fathers. Compared with fathers, moms reported a higher impression of caring for a youngster with DS on their social life, relationships with household and pals, time and power, {and professional} life.Families caring for a youngster with DS expertise appreciable social and financial impression, with an obvious higher burden of care on the mom than the daddy.
Discovery of DS-1971a, a Potent Selective NaV1.7 Inhibitor.

Small RNA-Mediated de Novo Silencing of Ac/Ds Transposons Is Initiated by Alternative Transposition in Maize.

Although Transposable Elements (TEs) comprise a main fraction of many larger eukaryotic genomes, most TEs are silenced by host protection mechanisms. The means by which in any other case lively TEs are acknowledged and silenced stays poorly understood. Here we analyzed two unbiased circumstances of spontaneous silencing of the lively maize Ac/Ds transposon system. This silencing is initiated by different transposition, a kind of aberrant transposition occasion that engages the termini of two close by separate TEs. Alternative transposition throughout DNA replication can generate Composite Insertions that include inverted duplications of the transposon sequences.

Rat Phospholipids ELISA kit

E02P1005-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A sandwich ELISA for quantitative measurement of Rat Phospholipids in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Phospholipids ELISA kit

E02P1005-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A sandwich ELISA for quantitative measurement of Rat Phospholipids in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Phospholipids ELISA kit

E03P1005-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A sandwich ELISA for quantitative measurement of Mouse Phospholipids in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Phospholipids ELISA kit

E03P1005-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A sandwich ELISA for quantitative measurement of Mouse Phospholipids in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Phospholipids ELISA kit

E03P1005-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A sandwich ELISA for quantitative measurement of Mouse Phospholipids in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Phospholipids ELISA kit

E04P1005-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A sandwich ELISA for quantitative measurement of Rabbit Phospholipids in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Phospholipids ELISA kit

E04P1005-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A sandwich ELISA for quantitative measurement of Rabbit Phospholipids in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Phospholipids ELISA kit

E04P1005-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A sandwich ELISA for quantitative measurement of Rabbit Phospholipids in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Phospholipids ELISA kit

E06P1005-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A sandwich ELISA for quantitative measurement of Goat Phospholipids in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Phospholipids ELISA kit

E06P1005-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A sandwich ELISA for quantitative measurement of Goat Phospholipids in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Phospholipids ELISA kit

E06P1005-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A sandwich ELISA for quantitative measurement of Goat Phospholipids in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Phospholipids ELISA kit

E07P1005-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A sandwich ELISA for quantitative measurement of Porcine Phospholipids in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Phospholipids ELISA kit

E07P1005-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A sandwich ELISA for quantitative measurement of Porcine Phospholipids in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Phospholipids ELISA kit

E07P1005-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A sandwich ELISA for quantitative measurement of Porcine Phospholipids in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Phospholipids ELISA kit

E08P1005-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A sandwich ELISA for quantitative measurement of Canine Phospholipids in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Phospholipids ELISA kit

E08P1005-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Canine Phospholipids in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Phospholipids ELISA kit

E08P1005-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A sandwich ELISA for quantitative measurement of Canine Phospholipids in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Phospholipids ELISA kit

E09P1005-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Monkey Phospholipids in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Phospholipids ELISA kit

E09P1005-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Monkey Phospholipids in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Phospholipids ELISA kit

E09P1005-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Monkey Phospholipids in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Phospholipids ELISA kit

E05P1005-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Guinea pig Phospholipids in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Phospholipids ELISA kit

E05P1005-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Guinea pig Phospholipids in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Phospholipids ELISA kit

E05P1005-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Guinea pig Phospholipids in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

PinPoint-FC 293T Platform Kit for Targeted Gene Insertion (includes PIN320A-1, PIN200A-1, PIN510A-1 & PIN600A-1)

PIN320A-KIT 1 Kit
EUR 4941
  • Category: PinPoint Integrase Tools

PinPoint-FC Murine iPSC Platform Kit for Targeted Gene Insertion (includes PIN340iPS-1, PIN200A-1, PIN510A-1 & PIN600A-1)

PIN340iPS-KIT 1 Kit
EUR 4941
  • Category: PinPoint Integrase Tools

Glycerol Assay Kit (For liquid samples)

abx090674-1Kit 1 Kit
EUR 613
  • Shipped within 5-10 working days.

Frit Kit

FRIT-KIT 1each
EUR 124
Description: Kit to create frits in capillaries. Includes formamide, Kasil-1, Kasil-1624 and a cleaving tool.

PinPoint-HR System for Platform Cell Line Generation & Retargeting (includes PIN400A-1, PIN200A-1, PIN510A-1, & PIN600A-1)

PIN400A-KIT 1 Kit
EUR 2798
  • Category: PinPoint Integrase Tools

Column Packing Kit

PACK-KIT 1pack
EUR 1035
Description: Column packing kit for pressure cells. Includes: HPREG regulator, TBNG10 tubing, CAP-75 capillary, and STRB5X2 stir bar.

PinPoint-FC System for Platform Cell Line Generation & Retargeting (includes PIN300A-1, FC200PA-1, PIN200A-1, PIN510A-1, & PIN600A-1)

PIN300A-KIT 1 Kit
EUR 2798
  • Category: PinPoint Integrase Tools

PCR Mycoplasma Detection Kit

M034-Kit Kit
EUR 266

Human TDP2 Assay Kit

TG1005-1 100 assays
EUR 537

Human TDP2 Assay Kit

TG1005-2 250 assays
EUR 660

PinPoint-HR System for Platform Cell Line Generation & Retargeting of AAVS1 Safe Harbor Locus (includes PIN410A-1, GE601A-1, PIN200A-1, PIN510A-1, & PIN600A-1)

PIN410A-KIT 1 Kit
EUR 4335
  • Category: PinPoint Integrase Tools

PinPoint-HR System for Platform Cell Line Generation & Retargeting of AAVS1 Safe Harbor Locus (includes PIN410A-1, CAS601A-1, PIN200A-1, PIN510A-1, & PIN600A-1)

PIN412A-KIT 1 Kit
EUR 4335
  • Category: PinPoint Integrase Tools

Cas9 Protein and T7 gRNA SmartNuclease Synthesis Kit

CAS400A-KIT 1 kit (10 rxn)
EUR 1110
  • Category: Cas9

CMV-hspCas9-T2A-Puro SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit

CASLV100PA-KIT 1 Kit
EUR 1132
  • Category: Cas9

CMV-hspCas9-EF1-GFP SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit

CASLV105PA-KIT 1 Kit
EUR 1132
  • Category: Cas9

MSCV-hspCas9-T2A-Puro SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit

CASLV120PA-KIT 1 Kit
EUR 1132
  • Category: Cas9

MSCV-hspCas9-EF1-GFP SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit

CASLV125PA-KIT 1 Kit
EUR 1132
  • Category: Cas9

Multiplex gRNA Kit + EF1-T7-hspCas9-H1-gRNA linearized SmartNuclease vector

CAS700A-KIT 10 rxn
EUR 1132
  • Category: Cas9

Multiplex gRNA Kit + CAG-T7-hspCas9-H1-gRNA linearized SmartNuclease vector

CAS720A-KIT 10 rxn
EUR 1132
  • Category: Cas9

Multiplex gRNA Kit + CMV-T7-hspCas9-H1-gRNA linearized SmartNuclease vector

CAS740A-KIT 10 rxn
EUR 1132
  • Category: Cas9

T7 gRNA SmartNuclease Synthesis Kit (includes CAS510A-1 & T7 IVT synthesis reagents)

CAS510A-KIT 1 Kit
EUR 805
  • Category: Cas9

DPA/Terbium for membrane fusion assay

80104 1SET
EUR 125
Description: Minimum order quantity: 1 unit of 1SET

SDIP/Europium for membrane fusion assay

80105 1SET
EUR 172
Description: Minimum order quantity: 1 unit of 1SET

Cas9 Nickase: CMV-hspCas9(D10A)-T2A-Puro SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit

CASLV200PA-KIT 1 Kit
EUR 1132
  • Category: Cas9

Cas9 Nickase: CMV-hspCas9(D10A)-EF1-GFP SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit

CASLV205PA-KIT 1 Kit
EUR 1132
  • Category: Cas9

Cas9 Nickase: MSCV-hspCas9(D10A)-T2A-Puro SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit

CASLV220PA-KIT 1 Kit
EUR 1132
  • Category: Cas9

Cas9 Nickase: MSCV-hspCas9(D10A)-EF1-GFP SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit

CASLV225PA-KIT 1 Kit
EUR 1132
  • Category: Cas9

Histamine Assay Kit

AKR-360 96 assays
EUR 519
Description: Histamine is naturally occurring in food, with high concentrations associated with spoiled and fermented foods. Exposure to high levels of histamine through the ingestion of food can cause symptoms similar to an allergic response. Our Histamine Assay Kit detects total histamine from food samples using a colorimetric probe. Reduction of the probe yields color development proportional the histamine levels in the sample. Absorbance at 450nm is read after a one hour incubation at 37C and histamine levels are calculated based on a histamine standard curve.

Glucose Assay Kit

abx090673-1Kit 1 Kit
EUR 237
  • Shipped within 5-10 working days.

ADA Assay Kit

abx090675-100tests 100 tests
EUR 237
  • Shipped within 5-10 working days.

Glutamate Assay Kit

abx096004-100Assays 100 Assays
EUR 441
  • Shipped within 5-10 working days.

Glutathione Assay Kit

abx096005-100Assays 100 Assays
EUR 378
  • Shipped within 5-10 working days.

Trehalase Assay Kit

abx096014-100Assays 100 Assays
EUR 551
  • Shipped within 5-10 working days.

Pyruvate Assay Kit

abx097982-100Assays 100 Assays
EUR 472
  • Shipped within 5-10 working days.

NADPase Assay Kit

abx097983-100Assays 100 Assays
EUR 504
  • Shipped within 5-10 working days.

Starch Assay Kit

abx097988-100Assays 100 Assays
EUR 441
  • Shipped within 5-10 working days.

Trehalose Assay Kit

abx097995-100Assays 100 Assays
EUR 472
  • Shipped within 5-10 working days.

ADA Assay Kit

abx098403-Hitachi7060R190ml2R290ml1 Hitachi 7060; R1: 90ml×2 R2: 90ml×1
EUR 739
  • Shipped within 5-12 working days.

ADA Assay Kit

abx098403-Hitachi7170R140ml4R220ml4 Hitachi 7170; R1: 40ml×4 R2: 20ml×4
EUR 801
  • Shipped within 5-12 working days.

ADA Assay Kit

abx098403-Hitachi7170R160ml4R260ml2 Hitachi 7170; R1: 60ml×4 R2: 60ml×2
EUR 911
  • Shipped within 5-12 working days.

ADA Assay Kit

abx098403-Toshiba40R150ml4R250ml2 Toshiba 40; R1: 50ml×4 R2: 50ml×2
EUR 786
  • Shipped within 5-12 working days.

Calcium Assay Kit

abx098414-Hitachi7020R140ml2R240ml2 Hitachi 7020; R1: 40ml×2 R2: 40ml×2
EUR 206
  • Shipped within 5-12 working days.

Calcium Assay Kit

abx098414-Hitachi7060R190ml1R290ml1 Hitachi 7060; R1: 90ml×1 R2: 90ml×1
EUR 206
  • Shipped within 5-12 working days.

Calcium Assay Kit

abx098414-Toshiba40R140ml2R240ml2 Toshiba 40; R1: 40ml×2 R2: 40ml×2
EUR 206
  • Shipped within 5-12 working days.

Calcium Assay Kit

abx098414-UniversalR140ml2R240ml2 Universal; R1: 40ml×2 R2: 40ml×2
EUR 206
  • Shipped within 5-12 working days.

Cholinesterase Assay Kit

abx098416-Hitachi7170R120ml1R25ml1 Hitachi 7170; R1: 20ml×1 R2: 5ml×1
EUR 300
  • Shipped within 5-12 working days.

Cholinesterase Assay Kit

abx098416-Hitachi7170R140ml3R230ml1 Hitachi 7170; R1: 40ml×3 R2: 30ml×1
EUR 316
  • Shipped within 5-12 working days.

Cholinesterase Assay Kit

abx098416-Hitachi7170R160ml2R230ml1 Hitachi 7170; R1: 60ml×2 R2: 30ml×1
EUR 316
  • Shipped within 5-12 working days.

Cholinesterase Assay Kit

abx098416-Toshiba40R140ml4R240ml1 Toshiba 40; R1: 40ml×4 R2: 40ml×1
EUR 331
  • Shipped within 5-12 working days.

Cholinesterase Assay Kit

abx098416-UniversalR160ml2R215ml2 Universal; R1: 60ml×2 R2: 15ml×2
EUR 316
  • Shipped within 5-12 working days.

Creatinine Assay Kit

abx098422-Hitachi7020R150ml3R250ml1 Hitachi 7020; R1: 50ml×3 R2: 50ml×1
EUR 519
  • Shipped within 5-12 working days.

Creatinine Assay Kit

abx098422-Hitachi7060R190ml2R260ml1 Hitachi 7060; R1: 90ml×2 R2: 60ml×1
EUR 472
  • Shipped within 5-12 working days.

Creatinine Assay Kit

abx098422-Toshiba120R140ml3R240ml1 Toshiba 120; R1: 40ml×3 R2: 40ml×1
EUR 566
  • Shipped within 5-12 working days.

Creatinine Assay Kit

abx098422-Toshiba120R150ml3R250ml1 Toshiba 120; R1: 50ml×3 R2: 50ml×1
EUR 519
  • Shipped within 5-12 working days.

Creatinine Assay Kit

abx098422-Toshiba40R150ml3R250ml1 Toshiba 40; R1: 50ml×3 R2: 50ml×1
EUR 519
  • Shipped within 5-12 working days.

Fructosamine Assay Kit

abx098427-Hitachi7020R140ml2R220ml1 Hitachi 7020; R1: 40ml×2 R2: 20ml×1
EUR 253
  • Shipped within 5-12 working days.

Fructosamine Assay Kit

abx098427-Hitachi7060R190ml2R245ml1 Hitachi 7060; R1: 90ml×2 R2: 45ml×1
EUR 253
  • Shipped within 5-12 working days.

Fructosamine Assay Kit

abx098427-Hitachi7170R120ml1R25ml1 Hitachi 7170; R1: 20ml×1 R2: 5ml×1
EUR 206
  • Shipped within 5-12 working days.

Fructosamine Assay Kit

abx098427-Hitachi7170R140ml12R240ml3 Hitachi 7170; R1: 40ml×12 R2: 40ml×3
EUR 222
  • Shipped within 5-12 working days.

Fructosamine Assay Kit

abx098427-Hitachi7170R140ml2R220ml1 Hitachi 7170; R1: 40ml×2 R2: 20ml×1
EUR 253
  • Shipped within 5-12 working days.

Glucose Assay Kit

abx098429-Hitachi7020R140ml4R240ml1 Hitachi 7020; R1: 40ml×4 R2: 40ml×1
EUR 222
  • Shipped within 5-12 working days.

Glucose Assay Kit

abx098429-Hitachi7060R190ml2R245ml1 Hitachi 7060; R1: 90ml×2 R2: 45ml×1
EUR 222
  • Shipped within 5-12 working days.

Glucose Assay Kit

abx098429-Hitachi7170R132ml4R28ml4 Hitachi 7170; R1: 32ml×4 R2: 8ml×4
EUR 222
  • Shipped within 5-12 working days.

Haptoglobin Assay Kit

abx098432-BeckmanR140ml1R210ml1 Beckman; R1: 40ml×1 R2: 10ml×1
EUR 347
  • Shipped within 5-12 working days.

Haptoglobin Assay Kit

abx098432-Hitachi7020R140ml1R210ml1 Hitachi 7020; R1: 40ml×1 R2: 10ml×1
EUR 347
  • Shipped within 5-12 working days.

Haptoglobin Assay Kit

abx098432-Hitachi7170R120ml1R25ml1 Hitachi 7170; R1: 20ml×1 R2: 5ml×1
EUR 269
  • Shipped within 5-12 working days.

Haptoglobin Assay Kit

abx098432-Toshiba40R140ml1R210ml1 Toshiba 40; R1: 40ml×1 R2: 10ml×1
EUR 347
  • Shipped within 5-12 working days.

Homocysteine Assay Kit

abx098434-Hitachi7060R160ml1R210ml1 Hitachi 7060; R1: 60ml×1 R2: 10ml×1
EUR 1036
  • Shipped within 5-12 working days.

Homocysteine Assay Kit

abx098434-Hitachi7170R130ml2R210ml1 Hitachi 7170; R1: 30ml×2 R2: 10ml×1
EUR 1036
  • Shipped within 5-12 working days.

Homocysteine Assay Kit

abx098434-Toshiba40R130ml2R210ml1 Toshiba 40; R1: 30ml×2 R2: 10ml×1
EUR 1036
  • Shipped within 5-12 working days.

Homocysteine Assay Kit

abx098434-UniversalR130ml2R210ml1 Universal; R1: 30ml×2 R2: 10ml×1
EUR 1036
  • Shipped within 5-12 working days.

Iron Assay Kit

abx098439-Hitachi7020R140ml1R210ml1 Hitachi 7020; R1:40ml×1 R2:10ml×1
EUR 206
  • Shipped within 5-12 working days.

Iron Assay Kit

abx098439-Hitachi7170R140ml1R210ml1 Hitachi 7170; R1:40ml×1 R2:10ml×1
EUR 206
  • Shipped within 5-12 working days.

Iron Assay Kit

abx098439-Hitachi7170R160ml1R215ml1 Hitachi 7170; R1:60ml×1 R2:15ml×1
EUR 222
  • Shipped within 5-12 working days.

Iron Assay Kit

abx098439-Toshiba40R140ml1R210ml1 Toshiba 40; R1:40ml×1 R2:10ml×1
EUR 206
  • Shipped within 5-12 working days.

Lipase Assay Kit

abx098442-BeckmanR180ml1R220ml1 Beckman; R1:80ml×1 R2:20ml×1
EUR 692
  • Shipped within 5-12 working days.

Lipase Assay Kit

abx098442-Hitachi7170R140ml2R220ml1 Hitachi 7170; R1:40ml×2 R2:20ml×1
EUR 692
  • Shipped within 5-12 working days.

Lipase Assay Kit

abx098442-Hitachi7170R160ml1R215ml1 Hitachi 7170; R1:60ml×1 R2:15ml×1
EUR 566
  • Shipped within 5-12 working days.

Lipase Assay Kit

abx098442-Toshiba40R140ml1R210ml1 Toshiba 40; R1:40ml×1 R2:10ml×1
EUR 441
  • Shipped within 5-12 working days.

Lipase Assay Kit

abx098442-UniversalR120ml1R25ml1 Universal; R1:20ml×1 R2:5ml×1
EUR 316
  • Shipped within 5-12 working days.

Magnesium Assay Kit

abx098445-Hitachi7020R140ml2R240ml2 Hitachi 7020; R1: 40ml×2 R2: 40ml×2
EUR 206
  • Shipped within 5-12 working days.

Magnesium Assay Kit

abx098445-Hitachi7060R190ml1R290ml1 Hitachi 7060; R1: 90ml×1 R2: 90ml×1
EUR 206
  • Shipped within 5-12 working days.

Magnesium Assay Kit

abx098445-Toshiba40R140ml2R240ml2 Toshiba 40; R1: 40ml×2 R2: 40ml×2
EUR 206
  • Shipped within 5-12 working days.

Magnesium Assay Kit

abx098445-Toshiba40R150ml2R250ml2 Toshiba 40; R1: 50ml×2 R2: 50ml×2
EUR 206
  • Shipped within 5-12 working days.

Microalbumin Assay KIt

abx098446-Hitachi7060R150ml1R210ml1 Hitachi 7060; R1: 50ml×1 R2: 10ml×1
EUR 363
  • Shipped within 5-12 working days.

Microalbumin Assay KIt

abx098446-Hitachi7060R150ml3R230ml1 Hitachi 7060; R1: 50ml×3 R2: 30ml×1
EUR 363
  • Shipped within 5-12 working days.

Microalbumin Assay KIt

abx098446-Hitachi7170R125ml1R25ml1 Hitachi 7170; R1: 25ml×1 R2: 5ml×1
EUR 269
  • Shipped within 5-12 working days.

Microalbumin Assay KIt

abx098446-Hitachi7170R150ml1R210ml1 Hitachi 7170; R1: 50ml×1 R2: 10ml×1
EUR 363
  • Shipped within 5-12 working days.

Myoglobin Assay Kit

abx098448-Hitachi7020R140ml1R210ml1 Hitachi 7020; R1: 40ml×1 R2: 10ml×1
EUR 1193
  • Shipped within 5-12 working days.

Myoglobin Assay Kit

abx098448-Hitachi7170R120ml1R25ml1 Hitachi 7170; R1: 20ml×1 R2: 5ml×1
EUR 692
  • Shipped within 5-12 working days.

Myoglobin Assay Kit

abx098448-Hitachi7170R140ml1R210ml1 Hitachi 7170; R1: 40ml×1 R2: 10ml×1
EUR 1193
  • Shipped within 5-12 working days.

Myoglobin Assay Kit

abx098448-Toshiba40R140ml1R210ml1 Toshiba 40; R1: 40ml×1 R2: 10ml×1
EUR 1193
  • Shipped within 5-12 working days.

NGAL Assay Kit

abx098449-Hitachi7020R140ml1R210ml1 Hitachi 7020; R1: 40ml×1 R2: 10ml×1
EUR 942
  • Shipped within 5-12 working days.

NGAL Assay Kit

abx098449-Hitachi7170R120ml1R25ml1 Hitachi 7170; R1: 20ml×1 R2: 5ml×1
EUR 566
  • Shipped within 5-12 working days.

NGAL Assay Kit

abx098449-Hitachi7170R140ml1R210ml1 Hitachi 7170; R1: 40ml×1 R2: 10ml×1
EUR 942
  • Shipped within 5-12 working days.

NGAL Assay Kit

abx098449-Toshiba120R140ml1R210ml1 Toshiba 120; R1: 40ml×1 R2: 10ml×1
EUR 942
  • Shipped within 5-12 working days.

NGAL Assay Kit

abx098449-Toshiba40R140ml1R210ml1 Toshiba 40; R1: 40ml×1 R2: 10ml×1
EUR 942
  • Shipped within 5-12 working days.

Prealbumin Assay Kit

abx098451-BeckmanR140ml1R210ml1 Beckman; R1: 40ml×1 R2: 10ml×1
EUR 222
  • Shipped within 5-12 working days.

Prealbumin Assay Kit

abx098451-Hitachi7170R132ml1R28ml1 Hitachi 7170; R1: 32ml×1 R2: 8ml×1
EUR 222
  • Shipped within 5-12 working days.

Prealbumin Assay Kit

abx098451-UniversalR160ml1R215ml1 Universal; R1: 60ml×1 R2: 15ml×1
EUR 253
  • Shipped within 5-12 working days.
We present that the inverted duplications of two Composite Insertions are transcribed to supply dsRNAs that set off the manufacturing of two distinct courses of siRNAs: a 24-nt class complementary to the TE terminal inverted repeats (TIRs) and non-coding sub-terminal areas, and a 21-22 nt class akin to the TE transcribed areas. Plants containing these siRNA-generating Composite Insertions exhibit decreased ranges of Ac transcript and heritable repression of Ac/Ds transposition. Further, we show that Composite Insertions can heritably silence in any other case lively parts in trans This examine paperwork the primary case of transposon silencing induced by different transposition and will signify a normal initiating mechanism for silencing of DNA transposons.