dna

Discovery of DS-1971a, a Potent Selective NaV1.7 Inhibitor.

Discovery of DS-1971a, a Potent Selective NaV1.7 Inhibitor.

A extremely potent, selective NaV1.7 inhibitor, DS-1971a has been found. Exploration of the left-hand phenyl ring of sulfonamide derivatives (I and II) led to the invention of novel collection of cycloalkane derivatives with excessive NaV1.7 inhibitory efficiency in vitro. As the right-hand heteroaromatic ring affected the mechanism-based inhibition legal responsibility of CYP3A4, substitute of this …

Discovery of DS-1971a, a Potent Selective NaV1.7 Inhibitor. Read More »